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The effects of mescaline include altered thinking processes, an altered sense of time and self-awareness, and closed- and open-eye visual phenomena. But unlike the tryptamine alkaloids, which act on serotonin receptors, mescaline is a phenethylamine that acts on dopamine receptors, producing hallucinogenic effects. Mescaline, more specifically 3,4,5-trimethoxyphenethylamine, is a plant alkaloid it is considered one of the classic hallucinogens alongside the psychedelic compounds LSD (derived from the ergot fungus) and psilocybin (from psilocybin mushrooms). The active ingredient in huachuma is the phenethylamine, mescaline. That pretty, emerald green, almost spineless columnar cactus in your neighbor’s front yard may be the sacred entheogen huachuma, the cactus used in ceremonies in South America for millennia. The global cultivation of Trichocereus pachanoi has also led to the creation of many cultivars, including “Juul’s Giant”, “Landfill”, and, notably, the Australian “Fields” and “Yowie”. Collectors trade cactus cuttings internationally and swap seeds. However, there are those who are aware! In fact, there are Trichocereus collectors and breeders the world over. It is used for landscaping in combination with other arid plants in minimalist gardens, and regularly sold in garden centers to many who are unaware of its entheogenic properties. Trichocereus pachanoi is a ubiquitous cactus. What we know as Trichocereus pachanoi is officially known as Echinopsis pachanoi, but most collectors, cultivators, and experts on the group continue to use Trichocereus. “ San Pedro” can be used to also refer to Trichocereus peruvianus ( Echinopsis peruviana) or Peruvian torch, Trichocereus bridgesii ( Echinopsis lageniformis) or Bolivian torch, and Trichocereus macrogonus ( Echinopsis macrogona). Given the concerns around the conservation status of peyote and the preservation of cultural practices, San Pedro is often suggested as an alternative for those who are curious about mescaline. In recent history, San Pedro has been overshadowed by peyote, also known as Lophophora williamsii. Also known as huachuma, it is one of many mescaline-containing cacti found throughout the Andes Mountains of Peru, Colombia, Ecuador, Bolivia, Argentina, and Chile. The San Pedro cactus, also known as Trichocereus pachanoi or torch cactus, is a columnar cactus from South America, named and described by Britton & Rose. The mescaline-containing San Pedro cactus – Trichocereus pachanoi